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KMID : 1101320040360020258
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Korean Journal of Clinical Laboratory Science
2004 Volume.36 No. 2 p.258 ~ p.268
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Preventive Effects of Cricket Extracts, Gryllus bimaculatus, against Toxicity Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Rats
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Lee Nam-Jin
Park Jong-Bae
Kim Dong-Kyu
Yun Chi-Young
Bae Hyung-Joon
Cho Jung-Hee
Kang Jong-Koo
Kim Yun-Bae
Hwang Seock-Yeon
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Abstract
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This study was carried out to investigate preventive effects of extracts of cricket, Gryllus bimaculatus, against the 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced toxicity in 7-week-old Sprague-Dawley male rats. Thirty five male rats were divided into 5 groups: one normal control group treated with vehicle and saline (G1); one TCDD-treated group by single intraperitoneal injection (G2); three preventive groups (G3, G4, and G5). The last three groups, G3, G4, and G5, were fed on cricket extracts (50, 100, and 200 ㎎/㎏, respectively) for 2 weeks before TCDD treatment. Various harmful effects were shown by TCDD treatment. The body weights of rats were lost by TCDD. In addition, severe hypertrophy and color change, and the weights gaining were found in the livers of TCDD-treated rats. It was observed that the cytoplasmic vacuolizations and inflammatory cell infiltration around portal triad in the liver. TCDD also elevated the serum activity levels of alanine transaminase(ALT) and aspartate transaminase(AST). However, those losses were compensated by cricket extracts treatment at the level of 200 ㎎/㎏. These findings indicate that cricket extracts may have protective effects against TCDD-induced toxicities in rats.
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KEYWORD
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Gryllus bimaculatus, Cricket extracts, TCDD, Lipid metabolism, Liver toxicity
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